New research shows that “bioengineered” blood vessels are able to incorporate living cells after being implanted in the human body. - NBCNewsMACH
Hemodialysis is typically administered through a fistula, a surgical connection between an artery and a vein that is easy to access; or through a graft, which connects the two blood vessels through a synthetic tube. Both approaches have shortcomings: Not all patients are good candidates for fistulas, and grafts are prone to clots and infections.
The researchers followed the patients for three years after they received their implants. Whenever a participant went in for routine surgery to fix or maintain their implant, researchers harvested a tiny square of their artificial vessel. All told, the researchers obtained samples from 13 patients. Subsequent analysis of the samples showed that the prebuilt matrix was filled in with the patients’ own cells.
“Your own stem cells crawl into the spaces, realize that they’re in a blood vessel, and then differentiate into your own tissue,” Humacyte CEO Jeffrey Lawson said. The analysis also showed evidence that the artificial vessels were able to heal themselves. In one sample, extracted about 10 months after implantation, new cells were seen growing around holesEniola-Adefeso called the results promising but said there’s much to learn about how the vessels perform — including how well they hold up over the long term.
The scientists at Yale and Humacyte are looking ahead, too. Lawson said the artificial blood vessels could someday be kept on hand in hospital emergency rooms.Want more stories about bioengineering?
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