A double mutation of the CCR5 gene, which a Chinese scientist intentionally edited into human embryos last year, is also associated with a 21% increased risk of dying early, a new study shows
Our genomes contain two copies of the CCR5 gene. It is known that people who carry two defective copies of this gene are highly resistant to HIV. But this double mutation of the CCR5 gene, which a Chinese scientist intentionally edited into human embryos last year, is also associated with a 21% increased risk of dying early, a new study showed.
The scientist, the twins and the experiment that geneticists say went too far When using CRISPR or other gene modifying technologies"we should be very careful in considering all the possible effects of a mutation," Rasmus Nielsen, a co-author of the new study and a professor in the department of integrative biology at University of California, Berkeley, told CNN."One mutation doesn't mean one effect." His new study was published Monday in the journal Nature Medicine.
Proposal for global moratorium on editing of inherited DNA is met with criticismTo answer this, Nielsen and his co-author Xinzhu Wei, a researcher at UC Berkeley, analyzed genetic and mortality data for over 400,000 individuals in the UK Biobank, a British database. They found that people who carry two copies of the mutation are more than 20% less likely to reach age 76 compared to people who have either one or no copies of the mutation.
Nielsen introduced a final word of caution against misinterpreting his work. Currently, scientists are experimenting with curing HIV infections through the use of engineered mutations. Even if a mutation might not be beneficial for people who are healthy, in people who are infected with HIV,"there's clearly a positive effect" when a mutation is introduced, said Nielsen."I would not like to see our results as any kind of call to stop those experiments or therapies for HIV.
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