Doctors feel that taking metformin is mostly safe, but cautioned about the lack of clinical studies.
Ariel Poler is a veteran angel investor in his early fifties who spends his days traveling around the Bay Area to meet with entrepreneurs. Now in his early fifties, he also thinks a lot more about his own health, so he makes an effort to keep his stress levels low by eating well and taking regular kite-surfing trips.
He's not alone. Metformin is undergoing a bit of a renaissance in Silicon Valley tech circles -- among people who do not have diabetes. But in recent years, researchers have studied the long-term effects and found that diabetics who took it for years wound up experiencing unintended health benefits, including a reduced cancer risk compared to the general population. Further studies of the drug in mice showed evidence of an improved life span.
"Some people told me it was a slam dunk for its anti-aging effects," he adds, over coffee in San Francisco."And some were skeptical, but most gave it a thumbs up that it's fairly safe." All of them agree that metformin's effects have been under-studied, in part because there isn't much of a financial incentive for the pharmaceutical industry to research the impact of an extremely cheap, generic drug. That could explain why doctors don't routinely recommend it to people without diabetes, and why metformin hasn't made it into the mainstream.
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